The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation.

The intronic long noncoding RNA ANRASSF1 recruits PRC2 to the RASSF1A promoter, reducing the expression of RASSF1A and increasing cell proliferation.

The down-regulation of the tumor-suppressor gene RASSF1A has been shown to increase cell proliferation in several tumors. RASSF1A expression is regulated through epigenetic events involving the polycomb repressive complex 2 (PRC2); however, the molecular mechanisms modulating the recruitment of this...

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Bibliographic Details
Main Authors: Felipe C Beckedorff, Ana C Ayupe, Renan Crocci-Souza, Murilo S Amaral, Helder I Nakaya, Daniela T Soltys, Carlos F M Menck, Eduardo M Reis, Sergio Verjovski-Almeida
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3749938?pdf=render

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http://europepmc.org/articles/PMC3749938?pdf=render

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