Further Developments towards a Minimal Potent Derivative of Human Relaxin-2

Further Developments towards a Minimal Potent Derivative of Human Relaxin-2

Human relaxin-2 (H2 relaxin) is a peptide hormone with potent vasodilatory and anti-fibrotic effects, which is of interest for the treatment of heart failure and fibrosis. H2 relaxin binds to the Relaxin Family Peptide Receptor 1 (RXFP1). Native H2 relaxin is a two-chain, three-disulfide-bond-contai...

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Bibliographic Details
Main Authors: Thomas N. G. Handley, Praveen Praveen, Julien Tailhades, Hongkang Wu, Ross A. D. Bathgate, Mohammed Akhter Hossain
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
human relaxin-2
RXFP1
7BP
B7-33
B9-31
fibrosis
Online Access:https://www.mdpi.com/1422-0067/24/16/12670

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https://www.mdpi.com/1422-0067/24/16/12670

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