Discovery of a Potent RIPK3 Inhibitor for the Amelioration of Necroptosis-Associated Inflammatory Injury

Discovery of a Potent RIPK3 Inhibitor for the Amelioration of Necroptosis-Associated Inflammatory Injury

Necroptosis is a form of regulated necrosis that requires the activation of receptor-interacting kinase 3 (RIPK3 or RIP3) and its phosphorylation of the substrate MLKL (mixed lineage kinase domain-like protein). Necroptosis has emerged as important cell death involved in the pathogenesis of various...

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Bibliographic Details
Main Authors: Kaijiang Xia, Fang Zhu, Chengkui Yang, Shuwei Wu, Yu Lin, Haikuo Ma, Xiaoliang Yu, Cong Zhao, Yuting Ji, Wenxiang Ge, Jingrui Wang, Yayun Du, Wei Zhang, Tao Yang, Xiaohu Zhang, Sudan He
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
necroptosis
RIPK3
kinase inhibitor
inflammatory diseases
Zharp-99
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.606119/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.606119/full

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