The expression of metalloproteinases in the lumbar disc correlates strongly with Pfirrmann MRI grades in lumbar spinal fusion patients
Introduction: Increased catabolism of the extracellular matrix is observed under degenerative disc disease (DDD). The cleavage of extracellular matrix proteins in the nucleus pulposus (NP) by either matrix metalloproteinases (MMPs) or a disintegrin and metalloproteinases with thrombospondin motifs (...
Main Authors: | , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2022-01-01
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Series: | Brain and Spine |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2772529422000133 |