The expression of metalloproteinases in the lumbar disc correlates strongly with Pfirrmann MRI grades in lumbar spinal fusion patients

The expression of metalloproteinases in the lumbar disc correlates strongly with Pfirrmann MRI grades in lumbar spinal fusion patients

Introduction: Increased catabolism of the extracellular matrix is observed under degenerative disc disease (DDD). The cleavage of extracellular matrix proteins in the nucleus pulposus (NP) by either matrix metalloproteinases (MMPs) or a disintegrin and metalloproteinases with thrombospondin motifs (...

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Bibliographic Details
Main Authors: Sanjay S. Aripaka, Rachid Bech-Azeddine, Louise M. Jørgensen, Jens D. Mikkelsen
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Brain and Spine
Subjects:
ADAMTS
Disc Degeneration
MMP
mRNA
Real-time PCR
Online Access:http://www.sciencedirect.com/science/article/pii/S2772529422000133

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