The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis.

The proton-sensing receptors TDAG8 and GPR4 are differentially expressed in human and mouse oligodendrocytes: Exploring their role in neuroinflammation and multiple sclerosis.

Acidosis is one of the hallmarks of demyelinating central nervous system (CNS) lesions in multiple sclerosis (MS). The response to acidic pH is primarily mediated by a family of G protein-coupled proton-sensing receptors: OGR1, GPR4 and TDAG8. These receptors are inactive at alkaline pH, reaching ma...

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Bibliographic Details
Main Authors: Fionä Caratis, Mikołaj Opiełka, Martin Hausmann, Maria Velasco-Estevez, Bartłomiej Rojek, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Bartosz Karaszewski, Aleksandra Rutkowska
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0283060&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0283060&type=printable

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