Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells”

Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells”

We have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-resistant chronic myeloid leukaemia stem cells (LSCs). By simultaneously disrupting mitochondrial respiration and inhibiting BCR-ABL kinase activity using the antibiotic tigecycline and imatinib respecti...

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Bibliographic Details
Main Authors: Lucie de Beauchamp, Pablo Baquero, Elodie M. Kuntz, Eyal Gottlieb, G. Vignir Helgason
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Molecular & Cellular Oncology
Subjects:
cancer stem cells
cml
metabolism
imatinib
leukaemia
oxphos
tyrosine kinase inhibitor
tigecycline
tca cycle
Online Access:http://dx.doi.org/10.1080/23723556.2017.1403532

Internet

http://dx.doi.org/10.1080/23723556.2017.1403532

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