Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells”
We have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-resistant chronic myeloid leukaemia stem cells (LSCs). By simultaneously disrupting mitochondrial respiration and inhibiting BCR-ABL kinase activity using the antibiotic tigecycline and imatinib respecti...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-01-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1403532 |
| _version_ | 1797677179653324800 |
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| author | Lucie de Beauchamp Pablo Baquero Elodie M. Kuntz Eyal Gottlieb G. Vignir Helgason |
| author_facet | Lucie de Beauchamp Pablo Baquero Elodie M. Kuntz Eyal Gottlieb G. Vignir Helgason |
| author_sort | Lucie de Beauchamp |
| collection | DOAJ |
| description | We have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-resistant chronic myeloid leukaemia stem cells (LSCs). By simultaneously disrupting mitochondrial respiration and inhibiting BCR-ABL kinase activity using the antibiotic tigecycline and imatinib respectively, we effectively eradicated LSCs and prevented disease relapse in pre-clinical animal models. |
| first_indexed | 2024-03-11T22:41:19Z |
| format | Article |
| id | doaj.art-ec868d7f8b7e45f2b669000b0e9fd9f3 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:19Z |
| publishDate | 2018-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-ec868d7f8b7e45f2b669000b0e9fd9f32023-09-22T09:10:59ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-01-015110.1080/23723556.2017.14035321403532Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells”Lucie de Beauchamp0Pablo Baquero1Elodie M. Kuntz2Eyal Gottlieb3G. Vignir Helgason4Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary & Life Sciences, University of GlasgowWolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary & Life Sciences, University of GlasgowCancer Research UK, Beatson Institute, Garscube EstateCancer Research UK, Beatson Institute, Garscube EstateWolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, College of Medical, Veterinary & Life Sciences, University of GlasgowWe have recently uncovered an abnormal increase in mitochondrial oxidative metabolism in therapy-resistant chronic myeloid leukaemia stem cells (LSCs). By simultaneously disrupting mitochondrial respiration and inhibiting BCR-ABL kinase activity using the antibiotic tigecycline and imatinib respectively, we effectively eradicated LSCs and prevented disease relapse in pre-clinical animal models.http://dx.doi.org/10.1080/23723556.2017.1403532cancer stem cellscmlcancer stem cellsmetabolismimatinibleukaemiaoxphostyrosine kinase inhibitortigecyclinetca cycle |
| spellingShingle | Lucie de Beauchamp Pablo Baquero Elodie M. Kuntz Eyal Gottlieb G. Vignir Helgason Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells” Molecular & Cellular Oncology cancer stem cells cml cancer stem cells metabolism imatinib leukaemia oxphos tyrosine kinase inhibitor tigecycline tca cycle |
| title | Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells” |
| title_full | Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells” |
| title_fullStr | Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells” |
| title_full_unstemmed | Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells” |
| title_short | Auto-Commentary on: “Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells” |
| title_sort | auto commentary on targeting mitochondrial oxidative phosphorylation eradicates therapy resistant chronic myeloid leukemia stem cells |
| topic | cancer stem cells cml cancer stem cells metabolism imatinib leukaemia oxphos tyrosine kinase inhibitor tigecycline tca cycle |
| url | http://dx.doi.org/10.1080/23723556.2017.1403532 |
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