Low-dose renin inhibitor and low-dose AT1-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes

Low-dose renin inhibitor and low-dose AT1-receptor blocker therapy ameliorate target-organ damage in rats harbouring human renin and angiotensinogen genes

We studied the effects of extremely low-dose human renin inhibition (aliskiren) with low angiotensin II receptor blockade (losartan) in a novel double-transgenic rat model harbouring both human renin and angiotensinogen genes. We found that low-dose aliskiren and low-dose losartan effectively reduce...

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Bibliographic Details
Main Authors: Ralf Dechend, Erdenechimeg Shagdarsuren, Petra Gratze, Anette Fiebeler, Bernhard Pilz, Silke Meiners, Wolfgang Derer, David L Feldman, Randy Webb, Dominik N Muller
Format: Article
Language:English
Published: SAGE Publications 2007-06-01
Series:Journal of the Renin-Angiotensin-Aldosterone System
Online Access:https://doi.org/10.3317/jraas.2007.008

Internet

https://doi.org/10.3317/jraas.2007.008

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