Lean Body Mass Harbors Sensing Mechanisms that Allow Safeguarding of Methionine Homeostasis

Lean Body Mass Harbors Sensing Mechanisms that Allow Safeguarding of Methionine Homeostasis

Protein-depleted states generate allosteric inhibition of liver cystathionine β-synthase (CBS), which governs the first enzymatic step of the transsulfuration cascade, resulting in upstream accretion of homocysteine (Hcy) in body fluids. A similar Hcy increase may arise from normal hepatocytes under...

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Bibliographic Details
Main Author: Yves Ingenbleek
Format: Article
Language:English
Published: MDPI AG 2017-09-01
Series:Nutrients
Subjects:
lean body mass
transthyretin
protein malnutrition
inflammatory disorders
methionine pool size
cystathionine-β-synthase
homocysteine
sarcopenia
Online Access:https://www.mdpi.com/2072-6643/9/9/1035

Internet

https://www.mdpi.com/2072-6643/9/9/1035

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