Myomedin replicas of gp120 V3 loop glycan epitopes recognized by PGT121 and PGT126 antibodies as non-cognate antigens for stimulation of HIV-1 broadly neutralizing antibodies

Myomedin replicas of gp120 V3 loop glycan epitopes recognized by PGT121 and PGT126 antibodies as non-cognate antigens for stimulation of HIV-1 broadly neutralizing antibodies

IntroductionImprinting broadly neutralizing antibody (bNAb) paratopes by shape complementary protein mimotopes represents a potential alternative for developing vaccine immunogens. This approach, designated as a Non-Cognate Ligand Strategy (NCLS), has recently been used for the identification of pro...

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Bibliographic Details
Main Authors: Veronika Daniel Lišková, Petr Kosztyu, Milan Kuchař, Jiří Černý, Shiv Bharadwaj, Hana Petroková, Eliška Vroblová, Michal Křupka, Michal Malý, Tereza Zosinčuková, Josef Šulc, Leona Rašková Kafková, Milan Raška, Petr Malý
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
HIV-1
glycoprotein 120
protein scaffold
protein engineering
broadly neutralizing antibody
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1066361/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1066361/full

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