Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A2

Multimodal regulation of the osteoclastogenesis process by secreted group IIA phospholipase A2

Increasing evidence points to the involvement of group IIA secreted phospholipase A2 (sPLA2-IIA) in pathologies characterized by abnormal osteoclast bone-resorption activity. Here, the role of this moonlighting protein has been deepened in the osteoclastogenesis process driven by the RANKL cytokine...

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Bibliographic Details
Main Authors: Maria Mangini, Rosa D’Angelo, Caterina Vinciguerra, Christine Payré, Gérard Lambeau, Barbara Balestrieri, Julia F. Charles, Stefania Mariggiò
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
group IIA secreted phospholipase A2 (sPLA2-IIA)
p38 SAPK
osteoclastogenesis
osteoclast syncytia
LLKYK cyclic peptide
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.966950/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.966950/full

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