Aurantio-Obtusin Attenuates Non-Alcoholic Fatty Liver Disease Through AMPK-Mediated Autophagy and Fatty Acid Oxidation Pathways

Aurantio-Obtusin Attenuates Non-Alcoholic Fatty Liver Disease Through AMPK-Mediated Autophagy and Fatty Acid Oxidation Pathways

Nonalcoholic fatty liver disease (NAFLD), manifested as the aberrant accumulation of lipids in hepatocytes and inflammation, has become an important cause of advanced liver diseases and hepatic malignancies worldwide. However, no effective therapy has been approved yet. Aurantio-obtusin (AO) is a ma...

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Bibliographic Details
Main Authors: Fei Zhou, Mingning Ding, Yiqing Gu, Guifang Fan, Chuanyang Liu, Yijie Li, Rong Sun, Jianzhi Wu, Jianchao Li, Xiaoyong Xue, Hongjuan Li, Xiaojiaoyang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
aurantio-obtusin
nonalcoholic fatty liver disease
autophagy
AMPK
PPARα
ACOX1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.826628/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.826628/full

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