Tacrolimus (FK506) causes disease aggravation in models for inherited peripheral myelinopathies

Tacrolimus (FK506) causes disease aggravation in models for inherited peripheral myelinopathies

Mice hetero- or homozygously deficient for myelin protein zero (P0+/−, P0−/− mice) are models for distinct forms of inherited de- or dysmyelinating neuropathies, respectively. P0+/− mice show a demyelinating neuropathy with a pathogenetic implication of CD8+ T-lymphocytes and macrophages, while P0−/...

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Bibliographic Details
Main Authors: Chi Wang Ip, Antje Kroner, Bianca Kohl, Carsten Wessig, Rudolf Martini
Format: Article
Language:English
Published: Elsevier 2009-02-01
Series:Neurobiology of Disease
Subjects:
Charcot–Marie–Tooth-disease
Schwann cell
Myelin
Treatment
Immunosuppression
Neuroprotection
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002532

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http://www.sciencedirect.com/science/article/pii/S0969996108002532

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