tRNA-like Transcripts from the <i>NEAT1-MALAT1</i> Genomic Region Critically Influence Human Innate Immunity and Macrophage Functions

tRNA-like Transcripts from the <i>NEAT1-MALAT1</i> Genomic Region Critically Influence Human Innate Immunity and Macrophage Functions

The evolutionary conserved <i>NEAT1-MALAT1</i> gene cluster generates large noncoding transcripts remaining nuclear, while tRNA-like transcripts (mascRNA, menRNA) enzymatically generated from these precursors translocate to the cytosol. Whereas functions have been assigned to the nuclear...

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Bibliographic Details
Main Authors: Martina Gast, Vanasa Nageswaran, Andreas W. Kuss, Ana Tzvetkova, Xiaomin Wang, Liliana H. Mochmann, Pegah Ramezani Rad, Stefan Weiss, Stefan Simm, Tanja Zeller, Henry Voelzke, Wolfgang Hoffmann, Uwe Völker, Stefan B. Felix, Marcus Dörr, Antje Beling, Carsten Skurk, David-Manuel Leistner, Bernhard H. Rauch, Tetsuro Hirose, Bettina Heidecker, Karin Klingel, Shinichi Nakagawa, Wolfram C. Poller, Filip K. Swirski, Arash Haghikia, Wolfgang Poller
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
immunology
innate immunity
immunogenetics
noncoding genome
tRNA biology
evolutionary genetics
Online Access:https://www.mdpi.com/2073-4409/11/24/3970

Internet

https://www.mdpi.com/2073-4409/11/24/3970

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