Design, Synthesis, In Vitro, and In Silico Studies of New <i>N</i><sup>5</sup>-Substituted-pyrazolo[3,4-<i>d</i>]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors

Design, Synthesis, In Vitro, and In Silico Studies of New <i>N</i><sup>5</sup>-Substituted-pyrazolo[3,4-<i>d</i>]pyrimidinone Derivatives as Anticancer CDK2 Inhibitors

CDK2 is a key player in cell cycle processes. It has a crucial role in the progression of various cancers. Hepatocellular carcinoma (HCC) and colorectal cancer (CRC) are two common cancers that affect humans worldwide. The available therapeutic options suffer from many drawbacks including high toxic...

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Bibliographic Details
Main Authors: Waheed A. Zaki, Selwan M. El-Sayed, Mohamed Alswah, Ahmed El-Morsy, Ashraf H. Bayoumi, Abrahman S. Mayhoub, Walaa H. Moustafa, Aeshah A. Awaji, Eun Joo Roh, Ahmed H.E. Hassan, Kazem Mahmoud
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Pharmaceuticals
Subjects:
anticancer agents
liver cancer
colorectal cancer
CDK2
pyrazolo[3,4-<i>d</i>]pyrimidine analogs
Online Access:https://www.mdpi.com/1424-8247/16/11/1593

Internet

https://www.mdpi.com/1424-8247/16/11/1593

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