Characterization of iRGD-Ligand Modified Arginine-Histidine-Rich Peptides for Nucleic Acid Therapeutics Delivery to αvβ3 Integrin-Expressing Cancer Cells

Characterization of iRGD-Ligand Modified Arginine-Histidine-Rich Peptides for Nucleic Acid Therapeutics Delivery to αvβ3 Integrin-Expressing Cancer Cells

Efficient and specific delivery of nucleic acid (NA) therapeutics to tumor cells is extremely important for cancer gene therapy. Various therapeutic strategies include delivery of DNA-therapeutics such as immunostimulatory or suicide genes and delivery of siRNA-therapeutics able to silence expressio...

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Bibliographic Details
Main Authors: Anna Egorova, Alexander Selutin, Marianna Maretina, Sergei Selkov, Vladislav Baranov, Anton Kiselev
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pharmaceuticals
Subjects:
nonviral gene delivery
siRNA delivery
receptor targeting
peptide-based carriers
integrin
iRGD
Online Access:https://www.mdpi.com/1424-8247/13/10/300

Internet

https://www.mdpi.com/1424-8247/13/10/300

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