Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers

Designed α-sheet peptides inhibit amyloid formation by targeting toxic oligomers

Previous studies suggest that the toxic soluble-oligomeric form of different amyloid proteins share a common backbone conformation, but the amorphous nature of this oligomer prevents its structural characterization by experiment. Based on molecular dynamics simulations we proposed that toxic interme...

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Bibliographic Details
Main Authors: Gene Hopping, Jackson Kellock, Ravi Pratap Barnwal, Peter Law, James Bryers, Gabriele Varani, Byron Caughey, Valerie Daggett
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-07-01
Series:eLife
Subjects:
amyloidosis
toxic oligomer
alpha-sheet
computational design
Online Access:https://elifesciences.org/articles/01681

Internet

https://elifesciences.org/articles/01681

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