Albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis

Albumin-bound paclitaxel augment temozolomide treatment sensitivity of glioblastoma cells by disrupting DNA damage repair and promoting ferroptosis

Abstract Background Temozolomide (TMZ) treatment efficacy in glioblastoma (GBM) patients has been limited by resistance in the clinic. Currently, there are no clinically proven therapeutic options available to restore TMZ treatment sensitivity. Here, we investigated the potential of albumin-bound pa...

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Bibliographic Details
Main Authors: Shanqiang Qu, Songtao Qi, Huayang Zhang, Zhiyong Li, Kaicheng Wang, Taichen Zhu, Rongxu Ye, Wanghao Zhang, Guanglong Huang, Guo-zhong Yi
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Glioblastoma
Temozolomide sensitivity
Albumin-bound paclitaxel
DNA damage repair
Ferroptosis
Online Access:https://doi.org/10.1186/s13046-023-02843-6

Internet

https://doi.org/10.1186/s13046-023-02843-6

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