Metastatic clear-cell renal cell carcinoma: a frequent NOTCH1 mutation predictive of response to anti-NOTCH1 CB-103 treatment

Metastatic clear-cell renal cell carcinoma: a frequent NOTCH1 mutation predictive of response to anti-NOTCH1 CB-103 treatment

Abstract Background Clear-cell renal cell carcinomas (ccRCCs) are malignant tumors with high metastatic potential and resistance to treatments occurs almost constantly. Compared to primary tumors, there are still limited genomic data that has been obtained from metastatic samples. Methods We aimed t...

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Bibliographic Details
Main Authors: Thi Oanh Bui, Eurydice Angeli, Morad El Bouchtaoui, Guillaume Gapihan, Van Tu Dao, Justine Paris, Christophe Leboeuf, Michael Soussan, Patrick Villarese, Marianne Ziol, Emmanuel Van Glabeke, Thi Huong Le, Jean-Paul Feugeas, Anne Janin, Guilhem Bousquet
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Experimental Hematology & Oncology
Subjects:
NOTCH1 mutation
Metastatic clear-cell renal cell carcinoma
Anti-NOTCH1 treatment
CB-103
Biomarker
Online Access:https://doi.org/10.1186/s40164-023-00408-z

Internet

https://doi.org/10.1186/s40164-023-00408-z

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