Identification of a novel fully human anti-toxic shock syndrome toxin (TSST)-1 single-chain variable fragment antibody averting TSST-1-induced mitogenesis and cytokine secretion

Identification of a novel fully human anti-toxic shock syndrome toxin (TSST)-1 single-chain variable fragment antibody averting TSST-1-induced mitogenesis and cytokine secretion

Abstract Background Staphylococcal superantigens are virulence factors that help the pathogen escape the immune system and develop an infection. Toxic shock syndrome toxin (TSST)-1 is one of the most studied superantigens whose role in toxic shock syndrome and some particular disorders have been dem...

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Bibliographic Details
Main Authors: Mahdieh Soezi, Somayeh Piri-Gavgani, Mostafa Ghanei, Mir Davood Omrani, Behnoush Soltanmohammadi, Kamran Pooshang Bagheri, Reza Ahangari Cohan, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh, Shohreh Khatami, Masoumeh Azizi, Fatemeh Rahimi-Jamnani
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Biotechnology
Subjects:
Staphylococcus aureus
Superantigen
Toxic shock syndrome toxin-1
Autoimmune diseases
Toxic shock syndrome
Single-chain variable fragment
Online Access:https://doi.org/10.1186/s12896-022-00760-8

Internet

https://doi.org/10.1186/s12896-022-00760-8

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