Columbianadin attenuates doxorubicin-induced cardiac injury, oxidative stress, and apoptosis via Sirt1/FOXO1 signaling pathway

Columbianadin attenuates doxorubicin-induced cardiac injury, oxidative stress, and apoptosis via Sirt1/FOXO1 signaling pathway

ABSTRACT Purpose: Oxidative stress and apoptosis contribute to the pathological basis of doxorubicin (DOX)-induced cardiotoxicity. Columbianadin (CBN) is one of the main bioactive constituents isolated from the root of Angelica pubescens. Herein, we intended to explore the potential role and molecu...

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Bibliographic Details
Main Authors: Bo Peng, Li Rao, Jiaolong Yang, Xiaowei Ku, Bin Kong, Wei Shuai, He Huang
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2023-06-01
Series:Acta Cirúrgica Brasileira
Subjects:
Doxorubicin
Cardiotoxicity
Oxidative Stress
Apoptosis
Sirtuin 1
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502023000100217&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502023000100217&tlng=en

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