Combination of T-DM1 and platinum-based chemotherapy in patient-derived xenograft models of muscle-invasive bladder cancer

Objective(s): To assess the efficacy and safety of T-DM1, as an anti-HER2 antibody-drug conjugate (ADC), alone and in combination with two platinum-based chemotherapy regimens in patient-derived xenografts (PDXs) of muscle-invasive bladder cancer (MIBC) established in immunodeficient mice. Materials...

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Bibliographic Details
Main Authors: Abolfazl Razzaghdoust, Samad Muhammadnejad, Mahmoud Parvin, Bahram Mofid, Masoumeh Zangeneh, Abbas Basiri
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2022-07-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
Online Access:https://ijbms.mums.ac.ir/article_20449_87d6a67779c06f4a5e633813764c61c6.pdf