Functional Specificity of the Members of the Sos Family of Ras-GEF Activators: Novel Role of Sos2 in Control of Epidermal Stem Cell Homeostasis

Functional Specificity of the Members of the Sos Family of Ras-GEF Activators: Novel Role of Sos2 in Control of Epidermal Stem Cell Homeostasis

Prior reports showed the critical requirement of Sos1 for epithelial carcinogenesis, but the specific functionalities of the homologous Sos1 and Sos2 GEFs in skin homeostasis and tumorigenesis remain unclear. Here, we characterize specific mechanistic roles played by Sos1 or Sos2 in primary mouse ke...

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Bibliographic Details
Main Authors: Fernando C. Baltanás, Cynthia Mucientes-Valdivieso, L. Francisco Lorenzo-Martín, Natalia Fernández-Parejo, Rósula García-Navas, Carmen Segrelles, Nuria Calzada, Rocío Fuentes-Mateos, Jesús M. Paramio, Xosé R. Bustelo, Eugenio Santos
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
Sos1
Sos2
GEF
KO
Ras signaling
keratinocytes
Online Access:https://www.mdpi.com/2072-6694/13/9/2152

Internet

https://www.mdpi.com/2072-6694/13/9/2152

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