Increased zinc levels facilitate phenotypic detection of ceftazidime-avibactam resistance in metallo-β-lactamase-producing Gram-negative bacteria

Increased zinc levels facilitate phenotypic detection of ceftazidime-avibactam resistance in metallo-β-lactamase-producing Gram-negative bacteria

Ceftazidime-avibactam is one of the last resort antimicrobial agents for the treatment of carbapenem-resistant, Gram-negative bacteria. Metallo-β-lactamase-producing bacteria are considered to be ceftazidime-avibactam resistant. Here, we evaluated a semi-automated antimicrobial susceptibility testin...

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Bibliographic Details
Main Authors: Michaela Simon, Roman G. Gerlach, Yvonne Pfeifer, Niels Pfennigwerth, Sören G. Gatermann, Agnes Schröder, Andreas Hiergeist, Axel Hamprecht, Tamara Rügamer, André Gessner, Jonathan Jantsch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Microbiology
Subjects:
Enterobacterales
Pseudomonas aeruginosa
metallo-β-lactamases
ceftazidime-avibactam
zinc
antimicrobial susceptibility testing
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.977330/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.977330/full

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