Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartment

Gαs regulates Glucagon-Like Peptide 1 Receptor-mediated cyclic AMP generation at Rab5 endosomal compartment

Objective: Upon activation, G protein coupled receptors (GPCRs) associate with heterotrimeric G proteins at the plasma membrane to initiate second messenger signaling. Subsequently, the activated receptor experiences desensitization, internalization, and recycling back to the plasma membrane, or it...

Full description

Bibliographic Details
Main Authors: Shravan Babu Girada, Ramya S. Kuna, Shilpak Bele, Zhimeng Zhu, N.R. Chakravarthi, Richard D. DiMarchi, Prasenjit Mitra
Format: Article
Language:English
Published: Elsevier 2017-10-01
Series:Molecular Metabolism
Subjects:
GLP-1 receptor
Rab5
Cyclic AMP
Insulin secretion
Gαs
Beta arrestin-1
Pancreatic beta cells
Online Access:http://www.sciencedirect.com/science/article/pii/S221287781630312X

Internet

http://www.sciencedirect.com/science/article/pii/S221287781630312X

Similar Items