Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

The V3-crown of the HIV-1 envelope protein largely elicits non-neutralizing antibodies. Here, the authors show that the V3-crown can be targeted by broadly neutralizing designed ankyrin repeat proteins recognizing two conformations one of which resembles CCR5- bound V3.

Bibliographic Details
Main Authors: Nikolas Friedrich, Emanuel Stiegeler, Matthias Glögl, Thomas Lemmin, Simon Hansen, Claus Kadelka, Yufan Wu, Patrick Ernst, Liridona Maliqi, Caio Foulkes, Mylène Morin, Mustafa Eroglu, Thomas Liechti, Branislav Ivan, Thomas Reinberg, Jonas V. Schaefer, Umut Karakus, Stephan Ursprung, Axel Mann, Peter Rusert, Roger D. Kouyos, John A. Robinson, Huldrych F. Günthard, Andreas Plückthun, Alexandra Trkola
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-27075-0

Internet

https://doi.org/10.1038/s41467-021-27075-0

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