Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration

Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration

The small GTPase Arl3 is important for the enrichment of lipidated proteins to primary cilia, including the outer segment of photoreceptors. Human mutations in the small GTPase Arl3 cause both autosomal recessive and dominant inherited retinal dystrophies. We discovered that dominant mutations resul...

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Bibliographic Details
Main Authors: Amanda M Travis, Samiya Manocha, Jason R Willer, Timothy S Wessler, Nikolai P Skiba, Jillian N Pearring
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
Arl3
photoreceptors
neuronal migration
Arl13B
RP2
retinal dystrophy
Online Access:https://elifesciences.org/articles/80533

Internet

https://elifesciences.org/articles/80533

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