Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9

Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9

Immunotherapy with targeted therapeutic antibodies is often ineffective in long-term responses in cancer patients due to resistance mechanisms such as overexpression of checkpoint molecules. Similar to T lymphocytes, myeloid immune cells express inhibitory checkpoint receptors that interact with lig...

Full description

Bibliographic Details
Main Authors: Chilam Chan, Marta Lustig, J. H. Marco Jansen, Laura Garcia Villagrasa, Leon Raymakers, Lois A. Daamen, Thomas Valerius, Geert van Tetering, Jeanette H. W. Leusen
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cancers
Subjects:
IgA
myeloid checkpoint inhibition
neutrophils
tumor sialylation
CD47/SIRPα
Online Access:https://www.mdpi.com/2072-6694/15/13/3405

Internet

https://www.mdpi.com/2072-6694/15/13/3405

Similar Items