Targeted treatment options for paediatric B-cell precursor acute lymphoblastic leukaemia patients with constitutional or somatic chromosome 21 alterations

Targeted treatment options for paediatric B-cell precursor acute lymphoblastic leukaemia patients with constitutional or somatic chromosome 21 alterations

Background: Chromosome 21 is affected in ∼60% of paediatric B-cell precursor acute lymphoblastic leukaemia (BCP-ALL) patients and includes somatic and constitutional gains, intrachromosomal amplification of chromosome 21 (iAMP21), and the translocation t(12;21) resulting in the ETV6::RUNX1 gene fusi...

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Bibliographic Details
Main Authors: Naomi Michels, Femke M. Hormann, Aurélie Boeree, Edwin Sonneveld, Anthony V. Moorman, Gabriele Escherich, Rosemary Sutton, H. Berna Beverloo, Rob Pieters, C. Michel Zwaan, Monique L. den Boer, Judith M. Boer
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:EJC Paediatric Oncology
Subjects:
Acute lymphoblastic leukemia
RAS
JAK
Paediatric
Chromosome 21
Down syndrome
Online Access:http://www.sciencedirect.com/science/article/pii/S2772610X23001381

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http://www.sciencedirect.com/science/article/pii/S2772610X23001381

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