Epigenetic Signatures Discriminate Patients With Primary Sclerosing Cholangitis and Ulcerative Colitis From Patients With Ulcerative Colitis

Epigenetic Signatures Discriminate Patients With Primary Sclerosing Cholangitis and Ulcerative Colitis From Patients With Ulcerative Colitis

BackgroundPrimary sclerosing cholangitis (PSC) is a chronic inflammatory liver disease affecting the intra- and extrahepatic bile ducts, and is strongly associated with ulcerative colitis (UC). In this study, we explored the peripheral blood DNA methylome and its immune cell composition in patients...

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Bibliographic Details
Main Authors: Manon de Krijger, Ishtu L. Hageman, Andrew Y. F. Li Yim, Jan Verhoeff, Juan J. Garcia Vallejo, Patricia H. P. van Hamersveld, Evgeni Levin, Theodorus B. M. Hakvoort, Manon E. Wildenberg, Peter Henneman, Cyriel Y. Ponsioen, Wouter J. de Jonge
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Immunology
Subjects:
primary sclerosing cholangitis
ulcerative colitis
DNA methylation/methylome
peripheral blood
850k methylation array
mass cytometry
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.840935/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.840935/full

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