Cardiac myosin super relaxation (SRX): a perspective on fundamental biology, human disease and therapeutics

The fundamental basis of muscle contraction ‘the sliding filament model’ (Huxley and Niedergerke, 1954; Huxley and Hanson, 1954) and the ‘swinging, tilting crossbridge-sliding filament mechanism’ (Huxley, 1969; Huxley and Brown, 1967) nucleated a field of research that has unearthed the complex and...

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Bibliographic Details
Main Authors: Manuel Schmid, Christopher N. Toepfer
Format: Article
Language:English
Published: The Company of Biologists 2021-02-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/10/2/bio057646