Causal relationships between gut microbiota and programmed cell death protein 1/programmed cell death-ligand 1: A bidirectional Mendelian randomization study

Causal relationships between gut microbiota and programmed cell death protein 1/programmed cell death-ligand 1: A bidirectional Mendelian randomization study

BackgroundMultiple clinical studies have indicated that the gut microbiota influences the effects of immune checkpoint blockade (ICB) therapy comprising PD-1/PD-L1 inhibitors, but the causal relationship is unclear. Because of numerous confounders, many microbes related to PD-1/PD-L1 have not been i...

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Bibliographic Details
Main Authors: Yu-Feng Huang, Wei-Ming Zhang, Zhi-Song Wei, Huan Huang, Qi-Yan Mo, Dan-Li Shi, Lu Han, Yu-Yuan Han, Si-Kai Nong, Guo-Xiang Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
PD-1/PD-L1
gut microbiota
bidirectional Mendelian randomization
pQTL
causality
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1136169/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1136169/full

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