Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats
Being overweight and obesity are world health problems, with a higher prevalence in women, defined as abnormal or excessive fat accumulation that increases the risk of chronic diseases. Excess energy leads to adipose expansion, generating hypertrophic adipocytes that produce various pro-inflammatory...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Aging Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1162747/full |
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| author | Verónica Salas-Venegas Verónica Salas-Venegas Roberto Santín-Márquez Roberto Santín-Márquez Ricardo Jair Ramírez-Carreto Ricardo Jair Ramírez-Carreto Yesica María Rodríguez-Cortés Yesica María Rodríguez-Cortés Agustina Cano-Martínez Armando Luna-López Anahí Chavarría Mina Konigsberg Norma Edith López-Díazguerrero |
| author_facet | Verónica Salas-Venegas Verónica Salas-Venegas Roberto Santín-Márquez Roberto Santín-Márquez Ricardo Jair Ramírez-Carreto Ricardo Jair Ramírez-Carreto Yesica María Rodríguez-Cortés Yesica María Rodríguez-Cortés Agustina Cano-Martínez Armando Luna-López Anahí Chavarría Mina Konigsberg Norma Edith López-Díazguerrero |
| author_sort | Verónica Salas-Venegas |
| collection | DOAJ |
| description | Being overweight and obesity are world health problems, with a higher prevalence in women, defined as abnormal or excessive fat accumulation that increases the risk of chronic diseases. Excess energy leads to adipose expansion, generating hypertrophic adipocytes that produce various pro-inflammatory molecules. These molecules cause chronic low-intensity inflammation, affecting the organism’s functioning and the central nervous system (CNS), inducing neuroinflammation. The neuroinflammatory response during obesity occurs in different structures of the CNS involved in memory and learning, such as the cortex and the hippocampus. Here we analyzed how obesity-related peripheral inflammation can affect CNS physiology, generating neuroinflammation and promoting cellular senescence establishment. Since some studies have shown an increase in senescent cells during aging, obesity, and neurodegenerative diseases, we proposed that cellular senescence participation may contribute to the cognitive decline in an obesity model of middle-aged female Wistar rats. The inflammatory state of 6 and 13 months-old female Wistar rats fed with a hypercaloric diet was measured in serum and CNS (cortex and hippocampus). Memory was evaluated using the novel object recognition (NOR) test; the presence of senescent markers was also determined. Our data suggest that the systemic inflammation generated by obesity induces a neuroinflammatory state in regions involved in learning and memory, with an increase in senescent markers, thus proposing senescence as a potential participant in the negative consequences of obesity in cognition. |
| first_indexed | 2024-04-09T17:41:13Z |
| format | Article |
| id | doaj.art-ecc38a7711c345af9328e425bbb96943 |
| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-04-09T17:41:13Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-ecc38a7711c345af9328e425bbb969432023-04-17T05:49:52ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-04-011510.3389/fnagi.2023.11627471162747Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar ratsVerónica Salas-Venegas0Verónica Salas-Venegas1Roberto Santín-Márquez2Roberto Santín-Márquez3Ricardo Jair Ramírez-Carreto4Ricardo Jair Ramírez-Carreto5Yesica María Rodríguez-Cortés6Yesica María Rodríguez-Cortés7Agustina Cano-Martínez8Armando Luna-López9Anahí Chavarría10Mina Konigsberg11Norma Edith López-Díazguerrero12Posgrado en Biología Experimental, Universidad Autónoma Metropolitana-Unidad Iztapalapa, Mexico City, MexicoDepartamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud (DCBS), Universidad Autónoma Metropolitana Iztapalapa, CDMX, Mexico City, MexicoPosgrado en Biología Experimental, Universidad Autónoma Metropolitana-Unidad Iztapalapa, Mexico City, MexicoDepartamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud (DCBS), Universidad Autónoma Metropolitana Iztapalapa, CDMX, Mexico City, MexicoPrograma de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, CDMX, Mexico City, MexicoUnidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, CDMX, Mexico City, MexicoPrograma de Doctorado en Ciencias Biomédicas, Universidad Nacional Autónoma de México, CDMX, Mexico City, MexicoUnidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, CDMX, Mexico City, MexicoDepartamento de Fisiología, Instituto Nacional de Cardiología “Ignacio Chávez”, CDMX, Mexico City, MexicoDepartamento de Investigación Básica, Instituto Nacional de Geriatría, CDMX, Mexico City, MexicoUnidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, CDMX, Mexico City, MexicoDepartamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud (DCBS), Universidad Autónoma Metropolitana Iztapalapa, CDMX, Mexico City, MexicoDepartamento de Ciencias de la Salud, División de Ciencias Biológicas y de la Salud (DCBS), Universidad Autónoma Metropolitana Iztapalapa, CDMX, Mexico City, MexicoBeing overweight and obesity are world health problems, with a higher prevalence in women, defined as abnormal or excessive fat accumulation that increases the risk of chronic diseases. Excess energy leads to adipose expansion, generating hypertrophic adipocytes that produce various pro-inflammatory molecules. These molecules cause chronic low-intensity inflammation, affecting the organism’s functioning and the central nervous system (CNS), inducing neuroinflammation. The neuroinflammatory response during obesity occurs in different structures of the CNS involved in memory and learning, such as the cortex and the hippocampus. Here we analyzed how obesity-related peripheral inflammation can affect CNS physiology, generating neuroinflammation and promoting cellular senescence establishment. Since some studies have shown an increase in senescent cells during aging, obesity, and neurodegenerative diseases, we proposed that cellular senescence participation may contribute to the cognitive decline in an obesity model of middle-aged female Wistar rats. The inflammatory state of 6 and 13 months-old female Wistar rats fed with a hypercaloric diet was measured in serum and CNS (cortex and hippocampus). Memory was evaluated using the novel object recognition (NOR) test; the presence of senescent markers was also determined. Our data suggest that the systemic inflammation generated by obesity induces a neuroinflammatory state in regions involved in learning and memory, with an increase in senescent markers, thus proposing senescence as a potential participant in the negative consequences of obesity in cognition.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1162747/fullobesityfemaleneuroinflammationsenescencecognitive deterioration |
| spellingShingle | Verónica Salas-Venegas Verónica Salas-Venegas Roberto Santín-Márquez Roberto Santín-Márquez Ricardo Jair Ramírez-Carreto Ricardo Jair Ramírez-Carreto Yesica María Rodríguez-Cortés Yesica María Rodríguez-Cortés Agustina Cano-Martínez Armando Luna-López Anahí Chavarría Mina Konigsberg Norma Edith López-Díazguerrero Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats Frontiers in Aging Neuroscience obesity female neuroinflammation senescence cognitive deterioration |
| title | Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats |
| title_full | Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats |
| title_fullStr | Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats |
| title_full_unstemmed | Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats |
| title_short | Chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence, promoting cognitive decline in middle-aged female Wistar rats |
| title_sort | chronic consumption of a hypercaloric diet increases neuroinflammation and brain senescence promoting cognitive decline in middle aged female wistar rats |
| topic | obesity female neuroinflammation senescence cognitive deterioration |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1162747/full |
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