Perfluorocarbons cause thrombocytopenia, changes in RBC morphology and death in a baboon model of systemic inflammation.

Perfluorocarbons cause thrombocytopenia, changes in RBC morphology and death in a baboon model of systemic inflammation.

A perfluorocarbon (PFC) investigated for treatment of traumatic brain injury (TBI) delivers oxygen to support brain function, but causes transient thrombocytopenia. TBI can cause acute inflammation with resulting thrombocytopenia; an interaction between the PFC effects and TBI inflammation might exa...

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Bibliographic Details
Main Authors: Heather F Pidcoke, Wilfred Delacruz, Maryanne C Herzig, Beverly S Schaffer, Sahar T Leazer, Chriselda G Fedyk, Robbie K Montogomery, Nicolas J Prat, Bijaya K Parida, James K Aden, Michael R Scherer, Robert L Reddick, Robert E Shade, Andrew P Cap
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0279694

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https://doi.org/10.1371/journal.pone.0279694

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