Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology

Development of nanobodies targeting hepatocellular carcinoma and application of nanobody-based CAR-T technology

Abstract Background Chimeric antigen receptor T (CAR-T) cell therapy, as an emerging anti-tumor treatment, has garnered extensive attention in the study of targeted therapy of multiple tumor-associated antigens in hepatocellular carcinoma (HCC). However, the suppressive microenvironment and individu...

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Bibliographic Details
Main Authors: Keming Lin, Baijin Xia, Xuemei Wang, Xin He, Mo Zhou, Yingtong Lin, Yidan Qiao, Rong Li, Qier Chen, Yuzhuang Li, Jinzhu Feng, Tao Chen, Cancan Chen, Xinyu Li, Hui Zhang, Lijuan Lu, Bingfeng Liu, Xu Zhang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Journal of Translational Medicine
Subjects:
HCC
Nanoparticle
Nanobody
Phage display
Nb-derived CAR-T cell therapy
Online Access:https://doi.org/10.1186/s12967-024-05159-x

Internet

https://doi.org/10.1186/s12967-024-05159-x

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