β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion

β-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion

Excessive interferon (IFN) responses often follow viral infection to induce pathology or even death. Here the authors show that a signaling adaptor, β-arrestin 2, enhances the cGAS/STING innate immunity signaling pathway to promote IFN-β production, but may be degraded in infected cells to serve as...

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Bibliographic Details
Main Authors: Yihua Zhang, Manman Li, Liuyan Li, Gui Qian, Yu Wang, Zijuan Chen, Jing Liu, Chao Fang, Feng Huang, Daqiao Guo, Quanming Zou, Yiwei Chu, Dapeng Yan
Format: Article
Language:English
Published: Nature Portfolio 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19849-9

Internet

https://doi.org/10.1038/s41467-020-19849-9

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