Screening of Pandemic Response Box Library Reveals the High Activity of Olorofim against Pathogenic <i>Sporothrix</i> Species

Screening of Pandemic Response Box Library Reveals the High Activity of Olorofim against Pathogenic <i>Sporothrix</i> Species

The increase in the prevalence and severity of fungal infections and the resistance to available antifungals highlights the imperative need for novel therapeutics and the search for new targets. High-content screening of libraries containing hundreds of compounds is a powerful strategy for searching...

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Bibliographic Details
Main Authors: Luana Pereira Borba-Santos, Rodrigo Rollin-Pinheiro, Yasmin da Silva Fontes, Giulia Maria Pires dos Santos, Glauber Ribeiro de Sousa Araújo, Anderson Messias Rodrigues, Allan J. Guimarães, Wanderley de Souza, Susana Frases, Antonio Ferreira-Pereira, Eliana Barreto-Bergter, Sonia Rozental
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Journal of Fungi
Subjects:
antifungal development
dimorphic fungi
antifungal target
sporotrichosis
olorofim
yeast
Online Access:https://www.mdpi.com/2309-608X/8/10/1004

Internet

https://www.mdpi.com/2309-608X/8/10/1004

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