Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC–MS/MS

Quantitative determination of lurbinectedin, its unbound fraction and its metabolites in human plasma utilizing ultra-performance LC–MS/MS

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<h4>Aims</h4> Ultra-performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) methods to quantify total lurbinectedin, its plasma protein binding to derive the unbound fraction and its main metabolites 1′,3′-dihydroxy-lurbinectedin (M4) and N-desmethyl-lurbinectedin (M6) in...

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Bibliographic Details
Main Authors: Nicholas King, Soledad Garcia-Martinez, Eider Alcaraz, Alba Grisalena, Rubin Lubomirov, Raquel Altares, Carlos Fernandez-Teruel, Andrés M. Francesch, Pablo M. Avilés, Salvador Fudio
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062662/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10062662/?tool=EBI

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