Anti-CD4 monoclonal antibody prevents chronic graft-versus-host disease in mice by inducing immune tolerance of CD8+ T cells and alleviating thymus injury

Anti-CD4 monoclonal antibody prevents chronic graft-versus-host disease in mice by inducing immune tolerance of CD8+ T cells and alleviating thymus injury

BackgroundChronic graft-versus-host disease (cGVHD) manifests with characteristics of autoimmune disease with organs attacked by pathogenic helper T cells. Recent studies have highlighted the role of T cells in cGVHD pathogenesis. Due to limited understanding of underlying mechanisms, preventing cGV...

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Bibliographic Details
Main Authors: Ziwei Wang, Ruiqi Li, Weijia Fu, Hui Cheng, Yan Zhang, Gusheng Tang, Jianmin Yang, Jianmin Wang, Xiong Ni
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
chronic graft-versus-host disease
CD4 + T cells
anti-CD4 monoclonal antibody
thymic recovery
immune tolerance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1460687/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1460687/full

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