Use of Lentiviral Particles As a Cell Membrane-Based mFasL Delivery System for In Vivo Treatment of Inflammatory Arthritis

Use of Lentiviral Particles As a Cell Membrane-Based mFasL Delivery System for In Vivo Treatment of Inflammatory Arthritis

During budding, lentiviral particles (LVP) incorporate cell membrane proteins in the viral envelope. We explored the possibility of harnessing this process to generate LVP-expressing membrane proteins of therapeutic interest and studied the potential of these tools to treat different pathologies. Fa...

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Bibliographic Details
Main Authors: Mario Mellado, José M. Rodríguez-Frade, Anabel Guedán, Pilar Lucas, Laura Martínez-Muñoz, Ricardo Villares, Gabriel Criado, Dimitri Balomenos, Hugh T. Reyburn
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Immunology
Subjects:
FasL
lentiviral particles
apoptosis
caspases
rheumatoid arthritis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00460/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00460/full

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