Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals

Continuous Manufacture and Scale-Up of Theophylline-Nicotinamide Cocrystals

The aim of the study was the manufacturing and scale-up of theophylline-nicotinamide (THL-NIC) pharmaceutical cocrystals processed by hot-melt extrusion (HME). The barrel temperature profile, feed rate and screw speed were found to be the critical processing parameters with a residence time of appro...

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Bibliographic Details
Main Authors: Steven A. Ross, Andrew P. Hurt, Milan Antonijevic, Nicolaos Bouropoulos, Adam Ward, Pat Basford, Mark McAllister, Dennis Douroumis
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceutics
Subjects:
cocrystals
hot-melt extrusion
scale-up
continuous manufacturing
X-ray
Rietveld refinement
Online Access:https://www.mdpi.com/1999-4923/13/3/419

Internet

https://www.mdpi.com/1999-4923/13/3/419

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