A reassessment of the Japanese clinical diagnostic criteria of familial hypercholesterolemia in a hospital-based cohort using comprehensive genetic analysis

A reassessment of the Japanese clinical diagnostic criteria of familial hypercholesterolemia in a hospital-based cohort using comprehensive genetic analysis

Background: Clinical diagnostic criteria of familial hypercholesterolemia (FH) in Japan include LDL cholesterol ​≥ ​180 ​mg/dL, Achilles tendon thickness ​≥ ​9.0 ​mm, and family history. However, few data exist regarding its validation. Design and Methods: A series of 680 participants, with a mean L...

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Bibliographic Details
Main Authors: Hayato Tada, Hirofumi Okada, Akihiro Nomura, Atsushi Nohara, Soichiro Usui, Kenji Sakata, Masayuki Takamura, Masa-aki Kawashiri
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Practical Laboratory Medicine
Subjects:
Achilles tendon thickness
Familial hypercholesterolemia
Proprotein convertase subtilisin/kexin type 9
Low-density lipoprotein receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2352551720301438

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http://www.sciencedirect.com/science/article/pii/S2352551720301438

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