FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment—a pharmacokinetic-pharmacodynamic study

FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment—a pharmacokinetic-pharmacodynamic study

Abstract Background Treatment of opiate addiction with opiate substitution treatment (e.g. methadone) is beneficial. However, some individuals desire or would benefit from abstinence but there are limited options to attenuate problems with opiate withdrawal. Preclinical and preliminary clinical evid...

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Bibliographic Details
Main Authors: L. M. Paterson, D. Barker, S. Cro, P. Mozgunov, R. Phillips, C. Smith, L. Nahar, S. Paterson, A. R. Lingford-Hughes
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Trials
Subjects:
Opiate
Addiction
Dependence
GABA-B
Baclofen
Methadone
Online Access:https://doi.org/10.1186/s13063-022-06821-9

Internet

https://doi.org/10.1186/s13063-022-06821-9

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