Simulation of the crosstalk between glucose and acetaminophen metabolism in a liver zonation model

The liver metabolizes a variety of substances that sometimes interact and regulate each other. The modeling of a single cell or a single metabolic pathway does not represent the complexity of the organ, including metabolic zonation (heterogeneity of functions) along with liver sinusoids. Here, we in...

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Detalles Bibliográficos
Main Authors: Kazuhiro Maeda, Shuta Hagimori, Masahiro Sugimoto, Yasuyuki Sakai, Masaki Nishikawa
Formato: Artigo
Idioma:English
Publicado: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fphar.2022.995597/full