Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy

Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy

Although short-term incubation of hepatocytes with oleic acid (OA) stimulates secretion of apolipoprotein B100 (apoB100), exposure to higher doses of OA for longer periods inhibits secretion in association with induction of endoplasmic reticulum (ER) stress. Palmitic acid (PA) induces ER stress, but...

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Bibliographic Details
Main Authors: Jorge Matias Caviglia, Constance Gayet, Tsuguhito Ota, Antonio Hernandez-Ono, Donna M. Conlon, Hongfeng Jiang, Edward A. Fisher, Henry N. Ginsberg
Format: Article
Language:English
Published: Elsevier 2011-09-01
Series:Journal of Lipid Research
Subjects:
apolipoprotein
endoplasmic reticulum
oleic acid
palmitic acid
docosahexaenoic acid
hepatoctyes
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520408557

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http://www.sciencedirect.com/science/article/pii/S0022227520408557

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