Xyloketal B Suppresses Glioblastoma Cell Proliferation and Migration in Vitro through Inhibiting TRPM7-Regulated PI3K/Akt and MEK/ERK Signaling Pathways

Xyloketal B Suppresses Glioblastoma Cell Proliferation and Migration in Vitro through Inhibiting TRPM7-Regulated PI3K/Akt and MEK/ERK Signaling Pathways

Glioblastoma, the most common and aggressive type of brain tumors, has devastatingly proliferative and invasive characteristics. The need for finding a novel and specific drug target is urgent as the current approaches have limited therapeutic effects in treating glioblastoma. Xyloketal B is a marin...

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Bibliographic Details
Main Authors: Wen-Liang Chen, Ekaterina Turlova, Christopher L. F. Sun, Ji-Sun Kim, Sammen Huang, Xiao Zhong, Yong-Yuan Guan, Guan-Lei Wang, James T. Rutka, Zhong-Ping Feng, Hong-Shuo Sun
Format: Article
Language:English
Published: MDPI AG 2015-04-01
Series:Marine Drugs
Subjects:
glioblastoma
xyloketal B
proliferation
migration
TRPM7
marine compound
Online Access:http://www.mdpi.com/1660-3397/13/4/2505

Internet

http://www.mdpi.com/1660-3397/13/4/2505

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