CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells

CXCR7 participates in CXCL12-mediated migration and homing of leukemic and normal hematopoietic cells

Abstract CXCR4 was the first receptor identified for CXCL12, but a second receptor, CXCR7, has also been described and its function in hematopoietic cells remains unknown. By inhibition of CXCR4 and/or CXCR7, we showed that CXCR7 participates in normal CD34+ and U937 cell migration and prevents down...

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Bibliographic Details
Main Authors: Rita de Cassia Carvalho Melo, Karla Priscila Viera Ferro, Adriana da Silva Santos Duarte, Sara Teresinha Olalla Saad
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Stem Cell Research & Therapy
Subjects:
CXCR7
Cell migration
Homing
Hematopoiesis
Leukemia
Online Access:http://link.springer.com/article/10.1186/s13287-017-0765-1

Internet

http://link.springer.com/article/10.1186/s13287-017-0765-1

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