Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach

Exploring inter-ethnic and inter-patient variability and optimal dosing of osimertinib: a physiologically based pharmacokinetic modeling approach

Purpose: This study aimed to develop and validate a physiologically based pharmacokinetic (PBPK) model for osimertinib (OSI) to predict plasma trough concentration (Ctrough) and pulmonary EGFRm+ (T790M and L858R mutants) inhibition in Caucasian, Japanese, and Chinese populations. The PBPK model was...

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Bibliographic Details
Main Authors: Feng Liang, Yimei Zhang, Qian Xue, Na Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
osimertinib
PBPK model
ethnic differences
inter-patients variability
optimal dosing regimens
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1363259/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1363259/full

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