Synthesis and Biological Evaluation of Cassane Diterpene (5α)-Vuacapane-8(14), 9(11)-Diene and of Some Related Compounds

Synthesis and Biological Evaluation of Cassane Diterpene (5α)-Vuacapane-8(14), 9(11)-Diene and of Some Related Compounds

A set of thirteen cassane-type diterpenes was synthesized and an expedient synthetic route was used to evaluate 14-desmethyl analogs of the most active tested cassane. The anti-inflammatory activities of these 13 compounds were evaluated on a lipopolysaccharide (LPS)-activated RAW 264.7 cell line by...

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Bibliographic Details
Main Authors: Houda Zentar, Fatin Jannus, Marta Medina-O’Donnell, José A. Lupiáñez, José Justicia, Ramón Alvarez-Manzaneda, Fernando J. Reyes-Zurita, Enrique Alvarez-Manzaneda, Rachid Chahboun
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
natural products
semisynthesis
cassane diterpenoids
anti-inflammatory activity
anti-cancer activity
Online Access:https://www.mdpi.com/1420-3049/27/17/5705

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https://www.mdpi.com/1420-3049/27/17/5705

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